Pharmacology of ASIC channels
نویسندگان
چکیده
منابع مشابه
Pharmacology of TRP Channels
TRP channels are a family of ion channels involved in a plethora of physiological sensory processes. Since their discovery they have attracted the attention of academic and non-academic laboratories with the aim of developing modulators that could be used as pharmacological tools for unveiling their physiological and pathological activities, and as therapeutic compounds for intervening in TRP d...
متن کاملPharmacology of cardiac potassium channels.
Cardiac K+ channels are membrane-spanning proteins that allow the passive movement of K+ ions across the cell membrane along its electrochemical gradient. They regulate the resting membrane potential, the frequency of pacemaker cells and the shape and duration of the cardiac action potential. Additionally, they have been recognized as potential targets for the actions of neurotransmitters and h...
متن کاملProton and non-proton activation of ASIC channels
The Acid-Sensing Ion Channels (ASIC) exhibit a fast desensitizing current when activated by pH values below 7.0. By contrast, non-proton ligands are able to trigger sustained ASIC currents at physiological pHs. To analyze the functional basis of the ASIC desensitizing and sustained currents, we have used ASIC1a and ASIC2a mutants with a cysteine in the pore vestibule for covalent binding of dif...
متن کاملTitle Pharmacology of Cardiac Potassium Channels
Cardiac K channels are cardiomyocyte membrane proteins that regulate K ion flow across the cell membrane on the electrochemical gradient, and determine the resting membrane potential and the cardiac action potential morphology and duration. Several K channels have been well studied in the human heart. They include the transient outward K current Ito1, the ultra-rapidly delayed rectifier current...
متن کاملPharmacology of voltage-gated proton channels.
Voltage-gated proton channels are highly proton selective ion channels that are present in many cells. Although their unitary conductance is 1000 times smaller than that of most ion channels, detection of single-channel currents supports their identification as channels rather than carriers. Proton channels are gated by membrane depolarization, but their absolute voltage dependence is also stro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: Membrane Transport and Signaling
سال: 2013
ISSN: 2190-460X
DOI: 10.1002/wmts.88